Ace was also featured in the Doctor Who Magazine comic strip sporadically, one of the few television companions to appear in it.

The molecular properties of a successful ACE inhibitor generally include low lipophilicity (with the exception of fosinopril) [ 11]. This indicates that the primary target of these drugs is the water-soluble (circulating) form of the enzyme. Accordingly, factors affecting circulating ACE activities have been implicated in the pathomechanism of cardiovascular disease. Circulating ACE concentration is controlled by a genetic polymorphism of the ACE gene (an insertion/deletion polymorphism, I/D polymorphism) [ 12], being implicated in systolic heart failure [ 13]. Sticova, E.; Jirsa, M. New insights in bilirubin metabolism and their clinical implications. World J. Gastroenterol. 2013, 19, 6398–6407. [ Google Scholar] [ CrossRef] Sawahata, M.; Sugiyama, Y.; Nakamura, Y.; Nakayama, M.; Mato, N.; Yamasawa, H.; Bando, M. Age-related and historical changes in the clinical characteristics of sarcoidosis in Japan. Resp. Med. 2015, 109, 272–278. [ Google Scholar] [ CrossRef] [ PubMed]

About

What the Doctor is aware of, but Ace is not, is that her arrival on Iceworld was no accident but part of a larger scheme stretching across the centuries and conceived by Fenric, [6] an evil that had existed since the beginning of the universe. Ace is a "Wolf of Fenric", one of many descendants of a Norseman tainted with Fenric's genetic instructions to help free it from its ancient prison so it can evolve humans into the Vampiric Haemovores, and a pawn in the complex game between it and the Doctor. After Fenric is defeated in 1943, Ace continues to journey with the Doctor. [7] At one point in the story, Ace offers to distract a guard so that the Doctor can free a prisoner. When the Doctor asks how she plans to divert the guard's attention she replies that she is "not a little girl". She proceeds to lead the guard away from his post by intriguing him with a combination of slightly suggestive innuendo towards the guard and cryptic musings about the Doctor's machinations. The scene suggests that she is aware of both her developed sexuality and the Doctor's manipulative tendencies. In Tales of the TARDIS, Ace reunited with an aged Seventh Doctor and discussed their adventures. They also discussed the meeting with Fenric and both apologised to each other falling out.

Iwatani, S.; Yamana, K.; Nakamura, H.; Nishida, K.; Morisawa, T.; Mizobuchi, M. A Novel Method for Measuring Serum Unbound Bilirubin Levels Using Glucose Oxidase-Peroxidase and Bilirubin-Inducible Fluorescent Protein (UnaG): No Influence of Direct Bilirubin. Int. J. Mol. Sci. 2020, 21, 6778. [ Google Scholar] [ CrossRef]Hegyi, T.; Kleinfeld, A.; Huber, A.; Weinberger, B.; Memon, N.; Shih, W.J.; Carayannopoulos, M.; Oh, W. Effects of Soybean Lipid Infusion on Unbound Free Fatty Acids and Unbound Bilirubin in Preterm Infants. J. Pediatr. 2017, 184, 45–50. [ Google Scholar] [ CrossRef] [ PubMed] Horsey, A.J.; Cox, M.H.; Sarwat, S.; Kerr, I.D. The multidrug transporter ABCG2: Still more questions than answers. Biochem. Soc. Trans. 2016, 44, 824–830. [ Google Scholar] [ CrossRef] [ PubMed]