The Renal Drug Handbook, 3rd Edition

Product Information

Summary of Product Characteristics: Quinine Sulfate Tablets 300mg. Teva UK Ltd. Revised April 2012. One limitation is that the handbook is a UK publication so some of the drugs and dosing recommendations are not relevant to the Australian situation. Perhaps a consideration for future editions might be to include some general comments on the use of various drug classes in patients with renal disease. If urinary Na+/K+ ratio is greater than 1, give 100mg daily. If the ratio is less than 1, give 200mg to 400mg daily. Summary of Product Characteristics: Spironolactone Tablets 100mg. Actavis UK Ltd. Revised June 2014. Use with caution in patients with glucose-6-phosphate dehydrogenase deficiency as there may be a risk of haemolysis in these patients.

Other information: Details given here are only relevant to the use of that particular drug in patients with impaired renal function or on renal replacement therapy. For more general information, please refer to the Summary of Product Characteristics for that drug. Avoid using oral potassium supplements in patients with serum potassium greater than 3.5 mEq/l. The recommended monitoring for potassium and creatinine is 1 week after initiation or increase in dose of spironolactone, monthly for the first 3 months, then quarterly for a year, and then every 6 months. Pregnancy and Lactation Pregnancy In addition to our own resources, we recommend the following resources for information about specific medicines in renal impairment. Vaginal candidiasis prophylaxis and treatment (four or more episodes yearly): 150mg every 72 hours for three doses followed by 150mg once weekly maintenance dose for six months. Summary of Product Characteristics: Quinine Sulfate Tablets 200mg. Teva UK Ltd. Revised April 2012.The tablets should be taken in the morning before breakfast with water or a very small amount of food. Advise patients to report any signs or symptoms of unexplained persistent nausea, decreased appetite, fatigue, vomiting, right upper abdominal pain, or jaundice, dark urine or pale faeces. Side Effects Welcome to the The Renal Drug Database. The information contained in this resource has been compiled from a wide range of sources and from the clinical experience of the editorial board of the UK Renal Pharmacy Group, all of whom are involved in the pharmaceutical care of renally-impaired patients. As such, some of the information contained in the monographs may not be in accordance with the licensed indications or use of the drug. Initial dose: 25mg once daily if serum potassium is less than or equal to 5mEq/l and serum creatinine is less than or equal to 2.5mg/dl.

Prescribers are advised to take into account the prevalence of resistance in various Candida species to fluconazole as alternative antifungal therapy secondary to treatment failure may be required. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 9th edition (2011) ed. Briggs, G., Freeman, R. and Yaffe, S. Lippincott Williams & Wilkins, Philadelphia. Advise patient on contraception required. If appropriate, advise patient to consider sperm cyropreservation. Advise patient to ensure breaking tablets into halves or quarters should be done out of the reach of food. Advise patient to wipe up any spilled powder with a damp disposable cloth in accordance with local guidance.Paediatric Formulary Committee. BNF for Children (online) London: BMJ Group, Pharmaceutical Press, and RCPCH Publications. Accessed on 03 June 2015. Treatment during pregnancy is not an indication for the termination of pregnancy, but a detailed ultrasound examination of fetal anatomy should be considered after first trimester use. Lactation Treatment given for seven to fourteen days in oropharyngeal candidiasis (longer if required in severely immunocompromised patients). The Preface outlines how to use the monographs and basic drug dosing advice including valuable information on the use of estimated glomerular filtration rate (eGFR). Physical Examination Procedures for Advanced Practitioners and Non-Medical Prescribers - 2nd ed. (2015)