Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., Pan, H., Wang, S., Wu, J., Wang, Y., Li, Z., Liu, J., and Jiang, J. D. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med 2004;10(12):1344-1351. View abstract. Pan, J. F., Yu, C., Zhu, D. Y., Zhang, H., Zeng, J. F., Jiang, S. H., and Ren, J. Y. Identification of three sulfate-conjugated metabolites of berberine chloride in healthy volunteers' urine after oral administration. Acta Pharmacol Sin. 2002;23(1):77-82. View abstract. Although it’s normal for your blood sugar levels to fluctuate throughout the day, prolonged high blood sugar levels can cause various health problems, including organ damage ( 5).

Zhu, B. and Ahrens, F. Antisecretory effects of berberine with morphine, clonidine, L- phenylephrine, yohimbine or neostigmine in pig jejunum. Eur J Pharmacol 12-9-1983;96(1-2):11-19. View abstract. Research shows that Berberine supports healthy blood sugar levels, that it maintains blood sugar levels before and after meals, and even supports healthy triglyceride levels, total and LDL cholesterol levels, and healthy blood pressure. Each veggie capsule boasts 600 mg of highly pure and highly concentrated berberine, putting it at the top of our list thanks both to its high dosage and to its high purity. On top of that, its purity is independently verified by third-party lab testing, and it’s certified non-GMO, gluten-free, and vegan-friendly. Marazzi G, Pelliccia F, Campolongo G, Quattrino S, Cacciotti L, Volterrani M, et al. Usefulness of nutraceuticals (Armolipid Plus) versus ezetimibe and combination in statin-intolerant patients with dyslipidemia with coronary heart disease. Am J Cardiol. 2015 Dec 15;116(12):1798-801. doi: 10.1016/j.amjcard.2015.09.023. View abstract. Ni, Y. X. [Therapeutic effect of berberine on 60 patients with type II diabetes mellitus and experimental research]. Zhong.Xi.Yi.Jie.He.Za Zhi.- Chinese Journal of Modern Developments in Traditional Medicine 1988;8(12):711-3, 707. View abstract.

Product overview

Saksena HC, Tomar VN, and Soangra MR. Efficacy of a new salt of Berberine Uni-Berberine in oriental sore. Current Medical Practice 1970;14:247-252. Zeng, X. and Zeng, X. Relationship between the clinical effects of berberine on severe congestive heart failure and its concentration in plasma studied by HPLC. Biomed Chromatogr 1999;13(7):442-444. View abstract. Cicero, AF, Rovati LC, and Setnikar I. Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. A single-blind clinical investigation. Arzneimittelforschung. 2007;57:26-30. View abstract. Furthermore, research suggests berberine may help support the blood-sugar-lowering effects of other diabetes medications when taken alongside them ( 3, 9, 10). Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. AMPK activation: a therapeutic target for type 2 diabetes? Diabetes Metab Syndr Obes 2014;7:241-53. View abstract.

Wen C, Wu L, Fu L, Zhang X, Zhou H. Berberine enhances the anti tumor activity of tamoxifen in drug sensitive MCF 7 and drug resistant MCF 7/TAM cells. Mol Med Rep. 2016;14(3):2250-6. View abstract. Though it’s branded as clinical grade, this berberine supplement doesn’t appear to be of higher dosage or quality than anything else on the market. It’s also certified free of many common allergens like gluten and soy, though the main downside of the berberine supplement from this lesser-known supplement manufacturer is its reliance on silica as a filler for its capsules. Higher-quality brands will opt for something more natural, like rice flour. Category winners Tai, Y. H., Feser, J. F., Marnane, W. G., and Desjeux, J. F. Antisecretory effects of berberine in rat ileum. Am J Physiol 1981;241(3):G253-G258. View abstract.Diabetes, high blood sugar levels, and obesity are also major risk factors for heart disease, and this supplement seems to help improve all of these conditions ( 7).

A dd to that the fact that it comes in a vegetarian capsule and doesn’t have much in the way of extra fillers and stabilizers, and you’ve got a winning formula for those who need a higher than usual dose of berberine. 7. Naturebell Berberine Plus Kaneda Y, Tanaka T, and Saw T. Effects of berberine, a plant alkaloid, on the growth of anaerobic protozoa in axenic culture. Tokai J Exp Clin Med 1990;15(6):417-423. Krol R, Zalewski A, and Maroko PR. Beneficial effects of berberine, a new positive inotropic agent, on digitalis-induced ventricular arrhythmias. Circulation 1982;66(suppl 2):56. Naturebell provides a solid berberine supplement with a high dose of 600 mg per capsule, which is nice for more aggressive supplementation routines shooting for 1200 mg per day in two separate doses. Aside from this, the purity and supplement design is good but not the absolute best . 8. Dr. Whitaker’s Clinical Grade BerberineChan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. View abstract.

Arana, B. A., Navin, T. R., Arana, F. E., Berman, J. D., and Rosenkaimer, F. Efficacy of a short course (10 days) of high-dose meglumine antimonate with or without interferon-gamma in treating cutaneous leishmaniasis in Guatemala. Clin Infect Dis 1994;18(3):381-384. View abstract. Some emerging evidence even suggests that berberine could be helpful for irritable bowel syndrome, but the causal pathways behind this are not yet clear.

Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. View abstract.