The Learning Journey Match It - Head To Tail Puzzle Game For Kids - Helps Interactive Child Development, Problem-Solving and Social Skills - 20 Self-Correcting Puzzle Sets - For 3+ Years

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Zhao L, Kanamaru S, Chaidirek C, Arisaka F (2003) P15 and P3, the tail completion proteins of bacteriophage T4, both form hexameric rings. J Bacteriol 185:1693–1700 Moreover, intramolecular disulphide cross-links engineered between AAA-1 and motif 2 residues in TthClpB, EcoClpB and yeast Hsp104 are also compatible with the fitted structure ( Figure 1E; K476C/E358C, Oguchi et al., 2012; G175C/R484C, H362C/Q473C E. coli numbering, Lee et al., 2003; G175C/S499C, Haslberger et al., 2007; Hsp104 K358C/D484C, Lipinska et al., 2013). However, this arrangement is not compatible with some of the engineered disulphide bonds observed in yeast Hsp104 ( Desantis et al., 2014) (D427C/E475C, D427C/E471C and E320C/N467C). Hu B, Margolin W, Molineux IJ, Liu J (2013) The bacteriophage T7 virion undergoes extensive structural remodeling during infection. Science 339:576–579

Lebedev AA, Krause MH, Isidro AL, Vagin A, Orlova EV, Turner J, Dodson EJ, Tavares P, Antson AA (2007) Structural framework for DNA translocation via the viral portal protein. EMBO J 26:1984–1994 The middle domains are known to form coiled-coils, with protein helices coiled together like the strands of a rope. However, previous efforts to work out the structure of the ClpB complex did not clearly establish where these coiled-coils were positioned relative to the rest of the ring. Motwani T, Lokareddy RK, Dunbar CA, Cortines JR, Jarrold MF, Cingolani G, Teschke CM (2017) A viral scaffolding protein triggers portal ring oligomerization and incorporation during procapsid assembly. Sci Adv 3:e1700423

The proximodistal trend is a pattern of motor skill development that begins with the core of the body and progresses outward. This refers to the development of skills such as head control, trunk control, shoulder control, and then arm and finger movement. It can be seen in infants as they learn to control teir heads before their shoulders or arms, and then their fingers. In older children and adults, it is seen in sports activities or other physical activities in which skills develop from the core outward. For example, a tennis player may start by learning how to move their legs correctly before learning how to move their arms and hands for a serve. Importance of Cephalocaudal Development Abrescia NG, Bamford DH, Grimes JM, Stuart DI (2012) Structure unifies the viral universe. Annu Rev Biochem 81:795–822 The result of adding 11 km, north plus 11 km, east is a vector with a magnitude of 15.6 km. Later, the method of determining the direction of the vector will be discussed.

Casjens S, Hendrix R (1988) Control mechanisms in dsDNA bacteriophage assembly. In: Calendar R (ed) The bacteriophages, vol 1. Plenum Press, New York Head-to-Tail Method: The head-to-tail method of graphically adding vectors is illustrated for the two displacements of the person walking in a city considered in the previous lesson. (a) Draw a vector representing the displacement to the east. (b) Draw a vector representing the displacement to the north. The tail of this vector should originate from the head of the first, east-pointing vector. (c) Draw a line from the tail of the east-pointing vector to the head of the north-pointing vector to form the sum or resultant vector \(\mathbf{D}\). The length of the arrow \(\mathbf{D}\) is proportional to the vector’s magnitude and is measured to be 10.3 units . Its direction, described as the angle with respect to the east (or horizontal axis) \(\theta \) is measured with a protractor to be \(\text{29}\text{.}1º\). Agirrezabala X, Martín-Benito J, Castón JR, Miranda R, Valpuesta JM, Carrascosa JL (2005) Maturation of phage T7 involves structural modification of both shell and inner core components. EMBO J 24:3820–3829 Step 3. If there are more than two vectors, continue this process for each vector to be added. Note that in our example, we have only two vectors, so we have finished placing arrows tip to tail. Step 5. To get the magnitude of the resultant, measure its length with a ruler. (Note that in most calculations, we will use the Pythagorean theorem to determine this length.)Fokine A, Rossmann MG (2014) Molecular architecture of tailed double-stranded DNA phages. Bacteriophage 4:e28281 Evilevitch A, Lavelle L, Knobler CM, Raspaud E, Gelbart WM (2003) Osmotic pressure inhibition of DNA ejection from phage. Proc Natl Acad Sci U S A 100:9292–9295 A) Basal and substrate-stimulated ATPase activities of ClpB wild type and indicated MD deletions were determined in the absence and presence of casein. Relative ATPase activations by casein were calculated (inset). ( B) Unfolding of Casein-YFP by BAP wild type and indicated MD deletions in the presence of ClpP was monitored by YFP fluorescence. Initial YFP fluorescence was set to 100%. ΔM1: ΔE410-Y455, ΔM2: ΔS456-E520, ΔM1/M2: ΔE410-E520. ( C) E. coli ΔclpB cells expressing the indicated plasmid-encoded clpB alleles under control of an IPTG-regulatable promoter were grown overnight at 30°C. Various dilutions (10 −1–10 −7) were spotted on LB plates containing the indicated IPTG concentration and incubated at 37°C for 24 hr. The proximodistal principle states that physical and cognitive development proceeds from the center of the body outward, towards the extremities. This concept suggests that development begins with trunk control and progresses to more distal parts, such as arms and legs. Additionally, this principle applies to the development of fine motor skills, such as grasping an object or using a tool. It is thought that this pattern of development allows for greater control and coordination of body movements which in turn aid in learning new skills and tasks. What is the Meaning of Proximodistal? Cardarelli L, Maxwell KL, Davidson AR (2011) Assembly mechanism is the key determinant of the dosage sensitivity of a phage structural protein. Proc Natl Acad Sci U S A 108:10168–10173