People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Micronutrients are major elements in the normal hair follicle cycle, playing a role in cellular turnover, a frequent occurrence in the matrix cells in the follicle bulb that are rapidly dividing. Management of alopecia is an essential aspect of clinical dermatology given the prevalence of hair loss and its significant impact on patients’ quality of life. The role of nutrition and diet in treating hair loss represents a dynamic and growing area of inquiry. In this review we summarize the role of vitamins and minerals, such as vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, iron, selenium, and zinc, in non-scarring alopecia. A broad literature search of PubMed and Google Scholar was performed in July 2018 to compile published articles that study the relationship between vitamins and minerals, and hair loss. Micronutrients such as vitamins and minerals play an important, but not entirely clear role in normal hair follicle development and immune cell function. Deficiency of such micronutrients may represent a modifiable risk factor associated with the development, prevention, and treatment of alopecia. Given the role of vitamins and minerals in the hair cycle and immune defense mechanism, large double-blind placebo-controlled trials are required to determine the effect of specific micronutrient supplementation on hair growth in those with both micronutrient deficiency and non-scarring alopecia to establish any association between hair loss and such micronutrient deficiency. A review article on zinc in patients with AA showed that four of the six case–control studies found low zinc levels in patients with AA as compared to healthy control groups [ 55]. One of these case–control studies was conducted by Kil et al. and included patients with MPHL, FPHL, and TE. The results of this study showed a strong correlation between zinc deficiency (< 70µg/dL) and hair loss [ 124]. Another study found a strong association between zinc deficiency and AA severity and chronicity [ 126]. However, in contrast to these studies, there are two case–control studies carried out in Iran [ 111] and Finland [ 113] that showed no significant correlation between zinc level and AA compared to the controls. Nuts and seeds have biotin, but how much you get depends. For instance, a one-fourth cup of roasted almonds has 1.5 micrograms, but just six walnut halves have 9.5 micrograms. A one-fourth cup of roasted sunflower seeds has 2.6 micrograms of biotin, more than the amount present in any other seed. A case–control study was conducted on 52 Indian subjects aged <20 years with premature canities (graying of the hair), with a matched control for each patient. The authors assessed and compared biotin, folic acid and vitamin B12 levels in both groups. The results showed a deficiency of vitamin B12 and folic acid in the patients evaluated and lower levels of biotin without any obvious biotin deficiency in the cases [ 40].

Biotin Complex w/ Selenium + Zinc - Bettervits Biotin Complex w/ Selenium + Zinc - Bettervits

Langerhans cells (LCs) are a subset of antigen-presenting cells that are distributed in the epidermis [ 12]. LCs but not KCs express CD39 (ecto-nucleoside triphosphate diphosphohydrolase 1; ENTPD-1) that potently hydrolyzes ATP into AMP [ 13, 14, 15], thereby assuming approximately 80% of the epidermal ATP hydrolysis [ 16]. Interestingly, epidermal LCs were absent in the skin lesions of patients with AE and of ZD mice [ 8, 9, 10]. The impaired ATP hydrolysis because of the disappearance of LCs leads to ATP-mediated inflammation in the epidermis, followed by the development of ICD. Therefore, the characteristic skin lesions in patients with AE are developed by aberrant ATP production from ZD–KCs and defective ATP hydrolysis due to loss of CD39-expressing LCs. Sweet potatoes have 2.4 micrograms of biotin in half a cup, about 8% of your daily value of biotin. So don’t assume taking biotin supplements will cure hair, skin or nail problems. “If you notice sudden changes in your hair, skin or nails, see your provider,” says Barth. “Don’t self-treat with biotin supplements without knowing the cause.” How much biotin do you need? Vitamin C acts as an antioxidant in our bodies and plays an important role in our skin health. Skin contains vitamin C, which supports collagen synthesis and helps protect against damage from UV-rays. As such, you may have seen vitamin C-infused serums or moisturizers in the beauty world. Ongoing research suggests topical vitamin C can reduce hyperpigmentation and tissue inflammation; however, it’s best to talk with a dermatologist to determine if this type of vitamin C is appropriate for you.Plus, B vitamins are important for your brain and nervous system, which could help with neurological symptoms of diabetes, such as neuropathy (nerve damage). We need more research on this, though. It’s true that many shampoo brands utilize biotin in their formulas as a way to combat hair loss. However, similar to the res earch around biotin supplements, the data to support hair growth from biotin-infused shampoo is limited. But there’s no harm really in giving this kind of shampoo a try if you want your hair to feel fuller — but don’t expect a magical regrowth of hair. Possible side effects of biotin While signs of biotin deficiency include hair loss, skin rashes, and brittle nails, the efficacy of biotin in supplements for hair, skin, and nails as a means to remedy these conditions is not supported in large-scale studies [ 25, 26]. In fact, only case reports have been used to justify the use of biotin supplements for hair growth. These case reports were in children and found that 3–5mg biotin daily could improve hair health after 3–4months in children with uncombable hair syndrome [ 37, 38]. In fact, biotin is primarily used for alopecia — a condition that causes hair loss in all sexes. “Biotin helps maintain hair growth and helps with inflammation,” Dr. Bergfeld says. “The hair follicle, the skin and the nails all benefit.”

Biotin Deficiency - StatPearls - NCBI Bookshelf

Although a relationship between vitamin D levels and AGA or TE is still being debated, most authors agree in supplementing vitamin D in patients with hair loss and vitamin D deficiency. Vitamin C intake is crucial in patients with hair loss associated with iron deficiency. There are no data to support the role of vitamin E in AGA or TE. BnD causes abnormalities in the fatty acid composition of skin, such as accumulation of odd-chain fatty acids and abnormal metabolism of long-chain polyunsaturated fatty acids [ 4, 23, 24]. In this study, we found that dietary BnD leads to ZnD. However, the decline in the serum zinc levels in BD mice was relatively slower than that in ZD mice [ 8]. Accordingly, although changes in terms of the body weight and survival rate were similar to those observed in ZD mice, the kinetics in BD mice was slower than that in ZD mice [ 8]. LCs were found to be almost absent in the epidermis of BD mice, thereby leading to enhanced ATP production in skin, and similar findings were observed for ZD mice. This aberrant ATP accumulation in the skin results in the recruitment of neutrophils [ 25] and development of characteristic skin lesions in patients with ZnD and BnD. Indeed, decreased serum zinc levels have been reported in some patients with BnD [ 26, 27, 28]. On the other hand, some studies have demonstrated normal serum zinc levels in patients with BnD [ 29, 30, 31]. We speculate that this discrepancy might be attributable for the duration of BnD. Reduced serum biotin and zinc levels have been recently reported in patients with male androgenetic alopecia, suggesting the close association between biotin and zinc [ 32]. We investigated how dietary BnD led to ZnD but the precise mechanisms could not be elucidated (data not shown). Further analysis is required for elucidating the underlying mechanisms. Although biotin and zinc aren’t considered hair loss treatments, they may contribute to healthy hair growth. Men with hair loss have been shown to have low or subnormal levels of zinc and biotin compared to men without male pattern hair loss. If you’re experiencing alopecia, your doctor may recommend certain biotin supplements or a higher biotin-rich diet as a way to combat hair loss. They may recommend upping your dosage to 3 milligrams (or 3,000 mcg) a day. What types of biotin are there?

Top 5 Biotin Supplements

Biotin, also known as vitamin B7, supports many of your body’s systems, including your nervous system, liver, eyes, hair, and skin. It helps the enzymes in your body carry out their jobs and keeps cells working as they should. Biotin(vitamin H or vitamin B7) is a B-complex vitaminthat acts as an essential coenzymefor five carboxylases: pyruvate carboxylase, 3-methylcrotonyl-CoA carboxylase, propionyl-CoA carboxylase, and coenzyme for acetyl-CoA carboxylases 1 and 2. [1] [2] [3] [4] These carboxylases help in several chemical processes in the cell, including gluconeogenesis, amino acid metabolism, and fatty acid synthesis. [1] [3] The Food and Nutrition Board of the Institute of Medicine recommends a daily dietary intake of 30 mcg/day to maintain good health. Biotin deficiency is very rare in those who take in a normal balanced diet. Mammals obtain biotin from food. Foods rich in biotin are egg yolk, liver, cereals (wheat, oats), vegetables (spinach, mushrooms), and rice. Dairy items and breast milk also contain biotin.

Biotin and Zinc: What You Need to Know - Particle

In 2017, Thompson et al. reviewed five other studies investigating the relationship between AA and iron [ 55]. None of these studies supported an association between AA and iron deficiency [ 27, 44, 111– 113]. In one study with the aim to determine the effects of isotretinoin on acne vulgaris in the skin, special care was taken to evaluate changes in the hair and hair growth. Thirty patients were evaluated over a 4- to 7-month treatment period, with examinations carried out using a FotoFinder dermoscope (FotoFinder Systems, Inc., Columbia, MD, USA) with TrichoScan® Professional software. Consistent with other findings, the authors reported a decrease in hair count, density, and percentage of anagen hairs [ 19]. There are a couple different ways to reap the benefits of biotin. Believe it or not, you may be already getting a decent dose without knowing it.

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While taking biotin supplements is fairly common and safe, there are a few side effects to be aware of. Sometimes, adding a high supplement of biotin into your diet can result in you having an upset stomach, as your gut adjusts to the new levels of vitamin. And if you can’t find the mega B-vitamin combination, you can buy biotin, zinc and vitamin C separately. Biotin shampoo

Biotin Hair Growth Tablets - Hair Skin and Nails Vitamins for

Eggs are a good source of biotin, a complex B vitamin that helps your body turn nutrients into energy and provides a variety of health benefits. (Photo Credit: Moment / Getty Images) You can enhance your hair, skin and nail health even without a supplement. A balanced diet with a variety of fruits, vegetables and protein is important for all three. Drink plenty of water, too. Hair loss is a common problem that may be improved with vitamin and mineral supplementation. Vitamins and minerals are important for normal cell growth and function and may contribute to hair loss when they are deficient. While supplementation is relatively affordable and easily accessible, it is important to know which vitamins and minerals are helpful in treating hair loss. Biotin is a water-soluble vitamin that serves as a co-enzyme for five carboxylases, namely, the covalently bound coenzyme for acetyl-CoA carboxylases 1 and 2, pyruvate carboxylase, propionyl-CoA carboxylase, and 3-methylcrotonyl-CoA carboxylase. These biotin-dependent carboxylases facilitate various metabolic reactions such as gluconeogenesis, fatty acid synthesis, and amino acid synthesis. Mammals cannot synthesize biotin by themselves; they obtain biotin through food and some gut microbiota produce biotin. Biotin deficiency (BnD) rarely occurs in people who consume a normal mixed diet [ 1, 2]. However, genetic deficiency of holocarboxylase synthetase and biotinidase, continuous consumption of raw egg whites, parenteral nutrition, and modified milk without biotin supplementation could result in BnD [ 1, 2, 3]. Patients with BnD [ 4] are known to develop clinical symptoms that are similar to those in patients with acrodermatitis enteropathica (AE), which is caused by loss-of-function mutations in Zrt-, Irt-like protein (ZIP) 4 [ 5, 6, 7]. The clinical symptoms of AE include characteristic skin lesions, alopecia, and diarrhea. Symptoms of zinc deficiency include thinning hair, acne, stunted growth, diarrhea, loss of appetite, and eye and skin lesions. There’s some indication that weight loss, slow wound healing, mental exhaustion, and an abnormal sense of taste could be due to zin deficiency.Because vitamin A is stored in our bodies, excessive quantities can be toxic, so be careful to not overdo vitamin A intake. The recommended daily allowance (RDA) is 900 micrograms daily for men and 700 micrograms daily for women. About one cup of raw carrots provides 900 mcg. To maximize your vitamin A potential, eat a well-rounded diet and include plenty of fruits and vegetables, along with dairy products, fish, liver, and fortified cereals. Vitamin C But why does biotin get superhero status when it comes to hair, skin and nail health? Maybe because biotin deficiency — not having enough biotin — can lead to: Most authors agree on iron supplementation in patients with iron or ferritin deficiency and hair loss