Girls Frozen Socks - Pack of 2

Product Information

An additional limitation is this review’s use of “colder” compared with “less cold” categories in interpreting findings. There was evidence to suggest that applying a relatively greater degree of cooling compared with a lesser degree may confer benefit in reducing the severity of CIPN. with only one of the studies, by Griffiths and colleagues (2018), reporting significant cold intolerance.

The Impact of Peripheral Cooling on Chemotherapy-Induced

Both direct application of cooling and use of compression to achieve fingertip cooling showed potential benefit. Additional studies are needed to further assess the validity of the findings in the Tsuyuki study and to discern benefit from compression compared with direct cooling. Estimates of CIPN incidence and prevalence vary, ranging from 29% to 68%, depending on time point of assessment, neurotoxic drug administered, and other factors ( Pereira et al. Evaluation of prevention interventions for taxane-induced dermatologic adverse events: A systematic review.Of note, the use of compression, while not a direct method of cooling, was considered in this review to be an indirect method of cooling given the resulting decrease in fingertip temperature documented within the study.

Frozen Sock - Etsy UK

Due to these variations, the impact of regional cooling controlling for drug regimens could not be undertaken here. This is further confounded by the fact that the mechanism of potential benefit of cooling in preventing CIPN is not completely understood ( Bandla et al. While a practical approach to discerning the impact of different cooling methods, it creates a limitation as there are not sufficient data available currently within the literature to populate a continuum of colder to less cold categories and the associated findings. Patients are entitled to understand available options that may reduce their risk of adverse events with peripherally neurotoxic chemotherapy agents.Patients may be counseled that there are limited data on using regional cooling to reduce the severity of CIPN. The difference in drug regimens used within the studies is of particular concern since the mechanism of nerve injury is theorized to differ between peripherally neurotoxic chemotherapies ( Shah et al. Matched case-control phase 2 study to evaluate the use of a frozen sock to prevent docetaxel-induced onycholysis and cutaneous toxicity of the foot.

Frozen | BIG W Frozen | BIG W

It should be emphasized that using a greater degree of cooling poses a small but serious risk of frostbite and may be associated with intervention-related discomfort. Incidence and disease burden of chemotherapy-induced peripheral neuropathy in a population-based cohort. Applying a relatively greater degree of regional cooling compared with a lesser amount may confer benefit in reducing the severity of CIPN. This self-controlled study included 29 breast cancer patients receiving anthracycline plus paclitaxel. One direct cooling study reported mixed results in terms of protective benefits with mostly nonsignificant findings related to benefit ( Sundar et al.A detailed description of this study and its results are outlined in the section titled “degree of cooling” in Table 1. Also of note, only two studies collected both objective and subjective measurements of peripheral neuropathy symptoms, and the combination of measurement tools used in these studies was variable ( Griffiths et al. Outcomes were measured with motor and sensory nerve conduction studies and were assessed at baseline and after 1, 3, and 6 months ( Sundar et al. Symptoms were recorded before the start of each cycle and 3 weeks after the last chemotherapy in the regional cooling group. Chemotherapy dose reduction due to chemotherapy induced peripheral neuropathy in breast cancer patients receiving chemotherapy in the neoadjuvant or adjuvant settings: A single-center experience.

Socks and What Can I Do About It? Why Does My Dog Eat Socks and What Can I Do About It?

To date, interventions to effectively prevent this toxicity have not been established, and interventions to treat CIPN have produced only modest results. Of note, the 2018 systematic review that examined the use of cooling to prevent chemotherapy-induced dermatologic toxicities reported a single case of frostbite within the eight studies reviewed that used frozen socks or gloves ( Marks et al.The Tsuyuki and colleagues (2016) study reported more compelling benefit from the use of compression with surgical gloves, which also achieved a relatively lesser degree of cooling. Patients received either three cycles of epirubicin and cyclophosphamide followed by three cycles of docetaxel or six cycles of docetaxel and cyclophosphamide. The limitations of this review include the small number of available studies on the topic, the small sample size in five of the six studies, variations in cooling methods, and inconsistent design of controls. Outcomes were measured using the National Cancer Institute’s Common Toxicity Criteria translated into Danish, with responses recorded at baseline and on day 20 after each cycle for cycles one through six ( Eckhoff et al. Peripherally neurotoxic agents received by these patients included paclitaxel, albumin-bound paclitaxel, docetaxel, and platinum-based drugs, and were administered alone, in combination with other agents on this list, or with other nonperipherally neurotoxic chemotherapy agents (see summary of the included studies in Table 1).