Evidently, it is necessary to use the same animal model, administered with extracts from the same extraction procedure at the same dosages for the same period to correctly evaluate the capability of different Dendrobium polysaccharides to decrease blood sugar levels.

Modern Supplements: Due to its potential health benefits and use in traditional medicine, dendrobium extract or powder is sometimes included in modern dietary supplements targeting fitness, energy, and endurance. compared immunomodulatory activities of polysaccharides from Dendrobium chrysotoxum (DCP), DCP-H obtained by hot water extraction (HWE) and DCP-E by enzyme-assisted extraction (EAE) [ 94]. Apoptosis induced by cell detachment was increased in TDB-treated cells and the formation of tumor in anchorage-independent growth was found to be reduced in response to the compound. Moscatilin also inhibits growth and induces apoptosis and mitotic catastrophe in human esophageal cancer cells, including squamous cell carcinoma (SCC) and adenocarcinoma (ADC) derived cell lines [ 36]. This study also found a variety of receptors in the CD gene family with increased levels of expression in the liver of diabetic rats.When taken by mouth: There isn't enough information to know if dendrobium is safe or what the side effects might be when taken by mouth. The protective effect of DO in diabetic rats may be associated with its antioxidant activity, as evidenced by the marked increase in the serum level of GSH-PX. However, the wealth of molecular information now known about neurodegenerative diseases progression leads to questioning on the efficacy of developed treatments.

The inhibitory effects of gigantol on EMT result in a decrease in the level of migration in H460 cells [ 40]. DOP-W3-b was thus obtained through a bioactivity-guided sequential isolation procedure based on in vitro Peyer’s patch-mediated immunomodulating activity assay.

The mice were injected with erianin (2 mg/kg) while the control group was injected with 5% DMSO intraperitoneally every other day for seven times in total. The active polysaccharide fraction of the mucilage was determined to have an average molecular weight of ~10kDa for the ratio of glucoside to mannoside (~1:10) and the degree of acetylation (~35%). The immunomodulatory activities of Dendronan ® in vivo in relation to cell mediated and humoral immunity was investigated using a long-term immunosuppressed mice model. At a concentration of 20 nM after 72 hours of treatment, T47D cells viability was also decreased, demonstrating that the treatment with low dosage over a long time could also inhibit the viability of T47D cells.

Moscatilin, gigantol, lusianthridin and dendroflorin exhibited cytotoxic properties (IC 50 < 200 µg/mL) and all of them inhibited the migration of the cells across the wound space in a time-dependent manner. However, after 48hr, moscatilin became the most potent compound, as a result of the substantial increase of its activity during the period of 24-48hr. Five bibenzyls and two bibenzyls glucosides were isolated from Dendrobium chrysotoxum to investigate their effect on cholinergic neurotransmission in the central and peripheral nervous systems. The hypoglycemic effect of the three species could be associated with the successful renovation of injured pancreatic islets, which was reflected not only by the histopathological changes of the pancreas but also by the recovery of decreased insulin release. Saliva and salivary glands biopsies from labial glands of patients were collected and examined by immunoreactivity and immunohistochemistry techniques.Auxiliary Stability Maintenance -- Herbal lung health essence auxiliary stability maintenance have protective membrane nourishment and purification. The difference between these two hypoglycemic activities of DCP might result from different lavaging dosages, treatment time and extraction procedure of DCP. Due to the high diversity of types of cancer, specific mechanisms of action have been explored to assign to Dendrobium spp. The appropriate dose of dendrobium depends on several factors such as the user's age, health, and several other conditions.

In Japan, since the Antiquity, Dendrobium moniliforme ("Fu-ran") has been known as "the orchid that gives long life to men".e. the amyloid plaques composed of amyloid β peptide (Aβ) and neurofibrillary tangles consisted of hyperphosphorylation tau protein [ 60].